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Initial preclinical and clinical studies have demonstrated ARA-290s broad therapeutic potential, particularly in conditions characterized by inflammation, tissue damage, and neuropathy

A loading period usually lasts 3 to 6 months before full effects are observed

Identify success criteria (50% pain reduction, specific functional milestone) guiding protocol duration and modification decisions

However, the subsequent biosafety problem has always been the focus of attention

These data were used to calculate specificity (72%), sensitivity (76%), positive predictive value (68%), and negative predictive value (79%) [274]

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