glp-1 gip dual agonist Tirzepatide, a GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction | Cardiovascular Diabetology Design of a novel long-acting

These oxidative modifications can further activate microglia through DAMP-associated pathways and interestingly, -synuclein misfolding has also been associated with microglia activation (Nagatsu et al., 2000

pubmed.ncbi.nlm.nih.gov/24791752/ Weschawalit S et al

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FREE RADICAL PROTECTION/REDUCED ACTIVE FORM: Glutathione plays a critical role in maintaining cellular health by directly neutralizing free radicals, as well as by maintaining the activity of vitamins C and E

And contrary to some fears that GLP-1 medications might increase the risk of depression and suicidality, as other weight loss drugs have in the past, this study found that these newer medications were linked to a lower risk of suicidal ideation, suicide attempts, and the intention to self-harm

PloS Negl.Trop