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When groups of 12 male Cynomolgus monkeys were exposed to concentrations of ethylene oxide at 90 or 180 mg/m 3 , for 7 h/day, 5 days per week, over 2 years, spermatogenic functions were found to differ from those of controls
The stratum corneum, the outermost barrier of dead keratinocytes, exists to keep molecules out
A5: Studies in animal models have reported favorable oral and subcutaneous bioavailability for AOD9604
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Second, detection step was validated by analyzing samples extracted with NADMED method but analyzed either by NADMED or LC-MS NADomics