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For people with T2D and atherosclerotic cardiovascular disease (ASCVD) or high CV risk, clinical guidelines developed by the American Diabetes Association and the European Association for the Study of Diabetes specifically recommend the use of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) or sodiumglucose cotransporter 2 inhibitors (SGLT2is) [9, 10], irrespective of baseline blood glucose levels or metformin use

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longum supplementation reduces both subjective bloating scores and objective measures of abdominal distension

Importantly, these anti-inflammatory effects appear to occur both through weight loss and through mechanisms entirely separate from it