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Traditional anticancer drugs, including alkylating agents, platinum-based compounds, anthracyclines, topoisomerase inhibitors, and antimicrotubule agents, often lack specificity, targeting all rapidly dividing cells rather than solely cancerous ones

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A number of studies have indicated that, as compared with mammals, the responses of the activities of many glucose metabolism-related key enzymes, such as GK, PFK and PK, are not sensitive to the increased dietary carbohydrate content in fish 36,37

Anyone with sarcoidosis, tuberculosis, or a history of hypercalcemia should not supplement vitamin D without physician oversight, and should likely avoid MK-677 altogether given its additional stimulation of the GH/calcitriol axis

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