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SsTyrA and OiTyrA were chosen as they are located at key phylogenetic boundaries within clade I and contain residues required for cofactor binding and catalysis (Figure S2, Data S2)

In an arthritic model experiment, silencing lncRNA ZFAS1 can mitigate inflammation and hyperplasia by competitively binding to miR-296-5p and regulating MMP-15 expression (249)

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