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The activated LATS1/LATS2 bind to the cofactor MOB1 and phosphorylate the downstream transcriptional coactivators YAP and TAZ (see Figure 2)

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As inflammation decreases, melanogenesis signalling may also reduce

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Still, that effect did not replicate at scale in the larger, longer Phase IIb study designed to confirm it which is the standard reason a compounds development gets discontinued rather than a sign the compound is unsafe

This would be especially beneficial for those who have to have their thyroid removed