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16 GLP-1 receptors are found in key brain regions that handle cognition and energy metabolism, including the neocortex, hippocampus, and hypothalamus

However, significant physiological differences between species must be considered when interpreting veterinary data for human clinical applications

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In contrast, PWA mice display overt metabolic perturbations, including overweight and impaired glucose homeostasis 46 , and may mimic the canonical human phenotype A of PCOS linked to hyperandrogenism, anovulatory cycles, and polycystic ovarian morphology 45

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