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Additional studies in cynomolgus monkeys have confirmed the potent dose-dependent, weight-lowering effects of chronic GLP-1R/GcgR co-agonism [78], supporting the translational promise of this novel balanced agonism for obesity and type 2 diabetes

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Cell Reports Medicine , 6(7), 102214

Herbal supplements with hypoglycemic effects should be used cautiously, as they may potentiate tirzepatide's glucose-lowering action and increase hypoglycemia risk, especially when combined with insulin or sulfonylureas

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