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When those peptide receptors are activated: The insulin response improves Hunger signals decrease Gastric emptying slows The fatty acid tail on the peptide enhances albumin binding and extends its half-life, allowing once-weekly subcutaneous injections to be effective

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Both GIP and GLP-1 receptors are expressed not only in pancreatic tissue but also in immune cells, adipose tissue, and vascular endothelium, though much of this evidence comes from preclinical studies

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