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Thus, in acromegaly, IGF-1 levels are elevated because of the somatotropinoma, but also because of the elevated insulin levels in the portal vein

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Moreover, signs of excess ROS are associated with the pathophysiology of other neurodegenerative diseases, such as Alzheimer's, or disorders affecting motor functional disturbances such as Amyotrophic Lateral Sclerosis or Huntington's disease 23