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Zhao S, Wang X, Zheng X, Liang X, Wang Z, Zhang J, et al

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pylori Helicobacter pylori Bcl-2 B-cell lymphoma 2 Bax Bcl-2-associated X LPS lipopolysaccharide PI3K phosphatidylinositol 3-kinase UC ulcerative colitis CD Crohns disease DSS dextran sulfate sodium TNBS 2,4,6-trinitrobenzene sulfonic acid FD functional dyspepsia IBS irritable bowel syndrome IBS-D diarrhea-predominant IBS IBS-C constipation-predominant IBS CC cancer cachexia Glossary References 1

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Notably, the acetylation-defective P53 mutant (P53 3KR) can indirectly inhibit the uptake of cysteine, decrease GSH production, and induce lipid ROS accumulation, leading to ferroptosis [67, 74]