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Targeting the p53-FOXO4 Axis: In senescent cells, the protein FOXO4 binds to p53 and sequesters it in the nucleus, preventing p53 from triggering cell death

GHK-Cu may prolong the anagen (growth) phase of hair and enlarge follicles

A damaged skin barrier is sensitive and may react to vitamin C

These findings are largely important especially in comparison of APAP-CYS and APAP treated cells, because the capability of APAP to reduce GSH levels was much lower than in the case of APAP-CYS conjugate

The pharmacokinetic data highlight the objective reduction in acetaldehyde levels, which is a more reliable indicator than subjective survey results

Acknowledgements We would like to thank Professor Catherine Chew, Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912 for her assistance in the preparation of this Application Sheet