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Conversion to NADH sustains mitochondrial electron transport, whereas NADPH supports reductive biosynthesis and glutathione-dependent antioxidant buffering [83]

Cai, F., Jin, S

Building healthy habits during therapy helps maintain long-term success

Patients should contact their healthcare provider if cold intolerance is accompanied by other signs of potential thyroid dysfunction, including severe fatigue that interferes with daily activities, unexplained weight gain despite continued medication use, significant hair thinning or loss, persistent constipation unresponsive to usual remedies, marked changes in skin texture (very dry or puffy skin), depression or cognitive changes, or muscle weakness and cramping

Adjustments should follow clinician guidance and individual sick-day protocols

It also delivers practical strategies for patient education, injection technique, adherence support, and safe dispensing to help prevent medication errors