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Research on GLP-1 therapy shows much of a plateau can be addressed by optimizing the current medication before assuming it has stopped working through dose titration, injection consistency, protein intake, and resistance training to protect muscle

The 12mg dose produced the headline results: 24.2% mean body weight reduction at 48 weeks

This paper finds bile acid-driven increases in enteroendocrine cell differentiation in a mouse model of VSG

The theoretical advantage of combining both agents is targeting multiple metabolic pathways: berberine enhances cellular insulin sensitivity, while GLP-1 improves beta-cell function and reduces appetite