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If thats true, weight loss is not the whole story but weight loss is likely an important contributor because excess adiposity promotes chronic inflammation, hormonal dysregulation, insulin resistance, and other processes linked to cancer development

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Nature 291 , 547553 (1981)

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Moreover, trafficking of the CAR-T cells is another problem as locally delivered CAR-T cells may not be able to reach distant tumors and target them effectively (188)

The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor