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The nuclei are ovoid or round and may be indented by cytoplasmic lipid droplets

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At least one serious adverse event occurred among 10.9% of the 36 mg orforglipron group, 10.3% of the 12 mg orforglipron group, 7.3% of those receiving 6 mg orforglipron and 8.8% of the placebo group

It increases insulin secretion from pancreatic -cells, reduces glucose-adjusted glucagon secretion, and improves insulin sensitivity more than what can be typically achieved through weight loss

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