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Subsequently, the cells were treated with BPTES (3 M, a glutaminase inhibitor that blocks the glutamine oxidation pathway), etomoxir (4 M, a CPT1A inhibitor, which is crucial for the transport of long-chain FAs from cytosol into mitochondria for oxidation), or UK5099 (2 M, an inhibitor of the glucose oxidation pathway that blocks the mitochondrial pyruvate carrier) successively, and oxygen consumption rate (OCR) was measured prior to and after the addition of each inhibitor

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An interesting study in rabbits found that supplementing with glycosaminoglycans with collagen slowed the progression of osteoarthritis

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These include alpha-lipoic acid (100 to 200 mg daily), methylsulfonylmethane (MSM) at 500 mg three times a day , and milk thistle supplements rich in silymarin