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Occupational exposure to noise: Evaluation, prevention, and control, 5362

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As a result, pyridoxine deficiency can lead to relevant neuropsychiatric manifestations, such as reduced neurotransmitter synthesis, depression, epilepsy, premature aging of neurons, paresthesias, cerebrovascular diseases, cognitive impairment and carpal tunnel syndrome (58) In contrast, pyridoxine may have therapeutic potential for treating depression or aggressive behavior, since pyridoxine plays a crucial role in the tryptophan-serotonin pathway (61, 62)

The oxidation of the DNA base guanine forms 8-OHdG due to hydroxyl radicals under conditions of excess oxidative stress 22

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Provides sustained anabolic signaling environment: Repeated stimulation of GH pulses increases cumulative exposure to downstream anabolic pathways