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We observed no evidence of dominance effects ( P = 0.80), indicating that the allelic dosage of the T allele contributes to efficacy in an additive manner

(Neither of these methods constitutes medical advice, and one should always consult a physician before altering a medication regimen.) For some patients, the goal is tolerability or maintenance after weight loss

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Similarly, the link between metformin and the activation of AMPK has been emphasized as the basis for the anti-proliferative effects of metformin (43)