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2 Pathological changes associated with osteoarthritis 2.1 Subchondral bone Subchondral bone plays a critical role in the pathogenesis and progression of OA, undergoing a series of pathological alterations that contribute to joint degeneration and pain (Zhu et al., 2020)

Such results, along with evidence of cardiovascular benefits (e.g

For weight management specifically, medications like Wegovy (also containing semaglutide) or Zepbound (tirzepatide) are FDA-approved for chronic weight management

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Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-proteincoupled receptor FFAR2

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