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The hyposality-promoted GSH/GSSG was weakened while the glutathione reductase (GR) activity was promoted by adding exogenous GSH and BSO

doi: 10.1016/j.neuron.2017.11.013 149 LonginettiE.FangF

Common reasons for excess melanin include prolonged sun exposure, hormonal imbalances, inflammation, and even certain medications, all of which can lead to dark spots, freckles, or an overall darker complexion

However, the MDA content was not increased in other types of statins like lovastatin, pravastatin, and rosuvastatin, which further confirmed the conclusion that only atorvastatin leads to ferroptosis

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Ndfip1 protected dopaminergic neurons via regulating mitochondrial function and ferroptosis in Parkinsons disease