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Several classes of medications may interact with semaglutide, including: Acetazolamide Anticonvulsants Antidepressants Antipsychotics Beta-blockers Bexarotene Ciprofloxacin HIV medications Corticosteroids Diuretics Hormones Isoniazid Additionally, caution is warranted when combining semaglutide with insulin, as this may elevate the risk of hypoglycemia