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Furthermore, loss of immunoreactivity to APE1 was observed in spinal cords of pre-symptomatic SOD1 G93A mice, suggesting that reduced levels of APE1 in motor neurons precede neurodegeneration (Manabe et al., 2001

Orphazymes arimoclomol fails to show efficacy in a specific ALS population

Li X, Song D, Leng SX

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Therefore its been postulated that fish oil supplements might help sickle patients