In reality, GLP-1 receptor agonists have been available for many years for the treatment of type 2 diabetes (Victoza, Trulicity, etc) and for weight loss (Saxenda), while tirzepatide is new in the last few years
References 1 MirbagheriMAdibniaVHughesBRWaldmanSDBanquyXHwangDK
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Por lo tanto, la alternativa a los aGLP-1 seran los iSGLT-2, que adems de reducir los eventos MACE, disminuyen la mortalidad, tienen efectos beneficiosos en la prevencin de hospitalizacin por insuficiencia cardiaca y cuentan con ensayos especficos en insuficiencia cardiaca y ERC
This disruption was particularly evident in the lateral transverse muscle number 3 (LT3) of abdominal A1 and A2 segments compared to control genotypes (100% penetrance, Figure 1A-C, Figure S1A-H)
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