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Techniques such as single-particle cryo-EM, synchrotron crystallography, multidimensional NMR, and Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) are now resolving the conformational landscapes of key HSV entry determinantsincluding gD, gB, gH/gL, and host receptors such as nectin-1, HVEM, and 3-O sulfated heparan sulfate (Figure 4) [68]

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Methodology The adopted method adopts a combination of field research and design-driven research

May 2009;89(5):1459-1467

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