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Acknowledgements The authors thank the investigators, study staff, and patients for their participation

Most patients notice appetite gradually returning between days 21-35 after their final injection, as circulating medication concentration drops below the appetite-suppression threshold

While the medication starts working as soon as its administered, significant appetite reduction usually takes a few days to weeks

IGF1 LR3 provides more direct and predictable effects on IGF-1 signaling, independent of pituitary function or feedback control

Wegovy is an injection and it is non-invasive whereas surgery is invasive and irreversible