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However, unlike GLP1 receptor agonists and SGLT2i, DPP4i was insignificant in terms of cardiovascular benefit and reduced risk of major adverse cardiovascular events

M1 microglia release cytokines such as TNF-, IL-1 and IL-6 and activate nuclear factor kappa-B (NF-B) pathways [16]

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Peptides that interface with this axis have been theorized to function as informational cues rather than simple stimulants

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