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I will keep everything in fridge in the future even thought the leaflet they send says otherwise, no wonder we all get confused

It ensures no structural degradations or heavy impurities remain in the vial

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This is particularly important because, like many herbal supplements, milk thistle can interact with certain prescription drugs, including those metabolized by the livers cytochrome P450 enzyme system, such as some cholesterol-lowering statins, blood thinners, and anti-diabetic medications

Wu Y, Zhang J, Yu S, Li Y, Zhu J, Zhang K, Zhang R