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Cagrilintide comprises a 37 amino acid linear synthetic peptide conjugated to a C20 fatty diacid through a hydrophilic linker at the lysine residue at position 1

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Intravenous or intraperitoneal injection of lipopolysaccharide (LPS) activates the zebrafish TLR4/NF-B pathway, eliciting systemic inflammatory responses that recapitulate pathological conditions such as neuroinflammation and enteritis

MDA: malondialdehyde

Its clinical trial safety profile was described as indistinguishable from placebo

The Akkermansia muciniphila component poses specific risks for people with Crohn disease or ulcerative colitis