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Butyrate activates a series of G protein-coupled receptors (GPCRs) that affect key metabolic processes, and GPCR41 and GPCR43 are expressed in immune cells (Kimura et al., 2013)

DOnofrio N, Servillo L, Giovane A, Casale R, Vitiello M, Marfella R, et al

While their mechanisms may differ, their combination has been proposed to provide complementary or synergistic actions

Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats

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