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Documented Outcomes Prescription semaglutide and tirzepatide have undergone Phase 3 randomized controlled trials demonstrating average weight loss of 10-22 percent over 68 weeks

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The reasons for this difference are not fully understood, but it is generally believed that the blood glucose-lowering effect of semaglutide, leading to reduced urinary glucose loss, may result in relative energy retention, which may reduce weight loss [107]

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