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All the compounds in the study had IC 50 values lower than allopurinol for XO inhibition and also than donepezil for AChE inhibition

EE and substrate oxidation rates In the respiratory chamber, all treatment groups had a slightly negative 24-h energy balance (mean 4.6 to 2.8%), which reached statistical significance for liraglutide 1.8 mg versus placebo (Supplementary Table 2), although energy balance for all participants was within an acceptable 10% limit (range 10.0 to 6.2%)

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