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How GLP-1 drugs work GLP-1 drugs, otherwise known as glucagon-like peptide-1 receptor agonists, work by mimicking the effects of a natural hormone called GLP-1

In a diabetes-driven kidney disease model, Glp1r / mice with streptozotocin-induced diabetes exhibited spontaneous kidney dysfunction and accelerated kidney damage as evidenced by their higher albumin-to-creatinine ratios, increased fibronectin levels, and lower cystatin C levels in the urine (70)

Healthy Fats Omega-3s and 2OG are healthy fats that can help increase GLP-1 in the body

Understanding insulin versus incretin-based therapies To fully grasp why Tresiba is not a GLP-1, it helps to understand the broader categories of diabetes medications and how they relate to each other