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Recent studies on Citrus aurantium indicate that the hexane fraction of CA (HFCA) stimulates NCI-H716 cells and induces membrane depolarization in NCI-H716, resulting in the secretion of glucagon-like peptide-1 (GLP-1), which regulates insulin secretion in pancreatic beta-cells

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The gut-liver axis plays a critical role in the pathogenesis of NAFLD, with altered gut microbiota contributing to hepatic inflammation and fat accumulation

A thorough characterization of the thiol-disulfide equilibria can be achieved by means of species-specific, so-called microscopic parameters, which are, in fact, well-established terms for acid-base systems 15,16