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Previous studies have emphasized that the energy deficit is a crucial factor for weight loss, characterized by the discordance between post-weight loss appetite and energy expenditure [54]

Kil, J., Pierce, C., Tran, H., Gu, R

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Interestingly, DA may also directly inhibit mitochondrial respiration [103] and DA oxidation generates toxic quinones and ROS leading to mitochondrial dysfunction [104]