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Some GLP1RAs (liraglutide and semaglutide) have proved to have positive effects on cardiovascular outcomes in T2DM

History of at least one self-reported unsuccessful dietary effort to lose body weight

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The most substantial early evidence for the potential health benefits of retatrutide comes from a Phase 2 clinical trial published in The New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023)

2020 Sep 3;11