Based on clinical trials, with the use of GLP-1 medications and lifestyle adjustments, patients can anticipate losing 10-18% of their body weight (based on the average weight loss in three 68 week clinical trials)
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However, a significant increase in Bifidobacterium, Dialister , and Alistipes was reported (73)
Heterogeneity in response to GLP-1 receptor agonists in type 2 diabetes in real-world clinical practice: insights from the DPV register - an IMI-SOPHIA study
Gastrointestinal symptoms during dose changes Nausea, constipation, and other GI symptoms are the most common side effects of GLP-1 therapy, and they tend to re-emerge whenever dosing changes occur
Future research should concentrate on discovering optimum microbiome biomarkers for therapy selection and creating microbiome-targeted adjuvant medicines