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12.Malluh A.A., Imseeh G., Abu-Osba Y.K.and Hamdan J.A

Yamada Y, Seino Y

Compared to exogenous recombinant GH (somatropin), Tesamorelin preserves the physiological pulsatility of endogenous secretion, maintaining better tissue response, avoiding GH-R desensitization, and presenting a more balanced metabolic profile (glycemic neutrality vs diabetogenic effect often documented with high-dose exogenous GH)

PS1.A Structure of Matter

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Ipamorelin, a selective ghrelin receptor agonist, works by binding to growth hormone secretagogue receptors in the pituitary gland, triggering targeted GH release without affecting cortisol or prolactin levels