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The risk is considered small for semaglutide and tirzepatide, but it exists

Average weight loss was 13.6% over 64 weeks

Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects

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In high-income nations with established diabetes care systems, GLP-1 receptor agonists exhibit advantageous cost-effectiveness ratios when accounting for cardiovascular and renal protective benefits, with incremental cost-effectiveness ratios generally falling below $50,000 per quality-adjusted life year (QALY) for high-risk patients (Kong et al

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