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Early intervention is critical because cognitive impairment can lead to more severe conditions, such as Alzheimers or other forms of dementia

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P21: Like PE-22-28, human dosing protocols are not established through clinical trials

Clin J Am Soc Nephrol 12:700710 Zelniker TA, Wiviott SD, Raz I, Im K, Goodrich EL, Furtado RHM et al (2019) Comparison of the effects of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors for prevention of major adverse cardiovascular and renal outcomes in type 2 diabetes mellitus: systematic review and meta-analysis of cardio

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Total cholesterol provides an overview, but the breakdown matters more