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FIGURE 7 The study was repeated using the same rat model to compare responses to 10, 25 and 50 g semaglutide applied to the intestinal surface versus 10-fold lower doses applied via the i.v
In the -cell, PC1/3 is up-regulated, resulting in increased processing of proglucagon to GLP-1 while DPP-4 is down-regulated in order to reduce degradation and enhance local intact GLP-1 concentrations
Based on case reports, this therapy seems most effective when initiated early in the patients presentation and could have reduced clinical benefit when initiated as rescue therapy.[9,10] HDI therapy is continued until there is a good clinical response (such as improved hemodynamics and acidosis)
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