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The peaks of ASP-SS-BBR + HNK and ASP-SS-BBR at approximately 2300 cm 1 are the conjugate telescopic vibrations of the benzene ring and -C=N, which are the characteristic peaks of BBR, but there are no such characteristic peaks at approximately 2300 cm-1 in ASP-BBR-PM@HNK, indicating that the hydrophobic side face is masked by the hydrophilic end after the formation of micelles

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This is the entire reason for Tirzepatide reconstitution with bac water