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Biol Psychiatry 83(9):720721

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Others have suggested that complement deposition on parasite membranes leads to assembly of membrane attack complex (MAC) that triggers Ca 2+ influx/overload, disruption of mitochondrial membrane potential, increase in mtROS production, and release of mitochondrial molecules into cytosol, thus signaling apoptosis and parasite death (Irigon et al., 2009)

J., Aliyari, R., Lu, S

Pharmacological blockade of GOAT or GHSR1a have yielded promising results in preclinical models of obesity (147150)