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We did not receive any public comments on our proposal and we are finalizing our proposal to determine copayment amounts for new and revised APCs using the same methodology that we implemented beginning in CY 2004
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The S tail extended motif makes contact with the binding site residues in one of the two WD40 domains whereas the upstream tail residues interact with the other WD40 domain, but at the face distal from the binding site (Supplementary Fig
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