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Its estimated that one out of every ten Americans have a vitamin B12 deficiency, making it one of the most common nutritional deficiencies in the U.S

Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action As a copper chelator, GHK-Cu modulates over 4,000 human genes, upregulating those involved in tissue remodeling (e.g., collagen I, III) and downregulating pro-inflammatory pathways like NF-B

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A few concerning trends emerged

Conditions involving intestinal inflammation, barrier dysfunction, or ulceration may respond to the peptide reparative effects, particularly when administered orally for direct tissue contact