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(2011) Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition, Autophagy , 7 , 176-187, doi: 10.4161/auto.7.2.14074

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Understanding how peptides interact with cellular signaling provides important context for why pathway-specific interventions like PTD-DBM represent a fundamentally different approach than conventional treatments

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Two of the proteolytic targeting chimeras, ARV-110 (NCT03888612) and ARV-471 (NCT04072952) have successfully made it to phase-II clinical trials, ARV-110 for metastatic castration-resistant prostate cancer, and ARV-471 for metastatic ER + /HER2 breast cancer