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doi: 10.1172/JCI29881 29 SchmidtFMWeschenfelderJSanderCMinkwitzJThormannJChittkaTet al

Circulating Fe 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)