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During soft and hard callus formation , peptides influence mesenchymal stem cell recruitment, osteoblast differentiation, chondrocyte activity, and angiogenesis

Endocrinology 129 , 14021408 (1991)

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Conclusion: FOXO4-DRI promotes the nuclear export of phosphorylated P53 by inhibiting the binding of FOXO4 to P53 in endothelial cells, thereby facilitating the apoptosis of senescent endothelial cells and alleviating aging

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