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Acknowledgments Financial support and sponsorship: The authors are supported by the research grants from the Uehara Memorial Foundation for Overseas postdoctoral fellowships (YN) and the NIH/NIDDK: R03-DK114642 (CMR), R01-DK122767 (CMR), and R01-DK124138 (CMR)

Unpublished results from the first phase II trial with the triple combination of semaglutide, cilofexor and/or firsocostat treatment for 24 weeks in 108 patients with NASH showed significant improvements in hepatic steatosis (measured with MRI) and liver injury (measured by serum alanine aminotransferase) in the combination treatment arm vs semaglutide monotherapy (56)

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The compounds discussed here are supplied strictly for laboratory research purposes and are not for human or animal consumption, medical use, or diagnostic use

A cell-culture result does not establish longer life, delayed ageing or clinical safety in people

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